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EuroClone
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InDevR Inc
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Carl Roth GmbH
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BioNano Genomics
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DIAGENODE DIAGNOSTICS
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BioNano Genomics
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MyOmicsDx Inc
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SERVA Electrophoresis
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NZYTech Inc
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bioMerieux gmbh
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Image Search Results
Journal: bioRxiv
Article Title: Rapid Identity and Quantity CQA Test for Multivalent mRNA Drug Product Formulations
doi: 10.1101/2022.08.31.506088
Figure Lengend Snippet: (a and b) Schematic of the HA and NA constructs used, respectively, with binding location of oligonucleotide captures shown above each construct. Captures shown in orange were the focus of performance assessment (c) Schematic representation of the VaxArray mRNA microarray slide showing 16 replicate microarrays, (d) individual microarray layout showing 9 replicate spots for each capture oligo, and fiducial markers in grey in top and bottom rows, (e) assay detection schemes represented herein, namely (i) coding region capture and polyT labeling, (ii) coding region capture and 5’ cap labeling, (iii) polyT capture and 5’ cap labeling, (iv) coding region capture and coding region labeling, and (v) polyT capture and coding region labeling.
Article Snippet: After the wash, samples were diluted in an optimized
Techniques: Construct, Binding Assay, Microarray, Labeling
Journal: bioRxiv
Article Title: Rapid Identity and Quantity CQA Test for Multivalent mRNA Drug Product Formulations
doi: 10.1101/2022.08.31.506088
Figure Lengend Snippet: Linearity of response for a variety of capture and detection schemes in monovalent mRNA samples, with NA in left column and HA in right column. (a) Coding region capture with polyT label as shown in Figure 1e(i), (b) polyT oligo capture with 5’ cap antibody label as shown in Figure 1e(iii), (c) Coding region capture and labeling with 5’ cap antibody label as shown in coding region capture with coding region labeling as shown in . Data points are the average of three replicates and error bars indicate ± 1 standard deviation. R 2 in upper left of each plot is based on a single linear regression.
Article Snippet: After the wash, samples were diluted in an optimized
Techniques: Labeling, Standard Deviation
Journal: bioRxiv
Article Title: Rapid Identity and Quantity CQA Test for Multivalent mRNA Drug Product Formulations
doi: 10.1101/2022.08.31.506088
Figure Lengend Snippet: Similarity of response for monovalent (•) and bivalent (○) 8-point dilution series using polyT oligo detection label for NA mRNA using (a) NA(i) coding region capture, (b) NA(iv) coding region capture, and for HA mRNA using (c) HA(i) coding region capture, and (d) HA(iv) coding region capture.
Article Snippet: After the wash, samples were diluted in an optimized
Techniques:
Journal: bioRxiv
Article Title: Rapid Identity and Quantity CQA Test for Multivalent mRNA Drug Product Formulations
doi: 10.1101/2022.08.31.506088
Figure Lengend Snippet: Similarity of response for monovalent (▴) and bivalent (Δ) 8-point dilution series using polyT oligo detection label for LNP-encapsulated NA mRNA using (a) NA(i) coding region capture, (b) NA(iv) coding region capture, and for LNP-encapsulated HA mRNA using (c) HA(i) coding region capture, and (d) HA(iv) coding region capture.
Article Snippet: After the wash, samples were diluted in an optimized
Techniques:
Journal: bioRxiv
Article Title: Rapid Identity and Quantity CQA Test for Multivalent mRNA Drug Product Formulations
doi: 10.1101/2022.08.31.506088
Figure Lengend Snippet: Similarity of response for bivalent LNP-encapsulated mRNA (Δ) and naked mRNA (•) 8-point dilution series using polyT oligo detection label for NA mRNA using (a) NA(i) coding region capture, (b) NA(iv) coding region capture, and for HA mRNA using (c) HA(i) coding region capture, and (d) HA(iv) coding region capture.
Article Snippet: After the wash, samples were diluted in an optimized
Techniques: